2-Chlorophenyl Cyclopentyl Ketone



 2-Chlorophenyl cyclopentyl ketone? is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. It acts as a pharmaceutical intermediate and also as an intermediate of ketamine.Chemical Name: 2-Chlorophenyl Cyclopentyl Ketone
Synonyms: (2-Chlorobenzoyl)cyclopentane; Cyclopentyl 2-Chlorophenyl Ketone; Cyclopentyl o-Chlorophenyl Ketone; (2-Chlorophenyl)cyclopentylmethanone;
CAS Number: 6740-85-8
Molecular Formula: C₁₂H₁₃ClO
Appearance: Clear Pale Yellow Oil
Melting Point: N/A
Molecular Weight: 208.68
Storage: Refrigerator
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals,Applications: 2-Chlorophenyl Cyclopentyl Ketone is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. 2-Chlorophenyl cyclopentyl ketoneStep 1: Peroxyacid oxidation (requires isomerization of safrole) or Wacker oxidation (an elegant catalytic oxidation) produces the ketone “PMK” (piperonyl methyl ketone, also known as 3,4-MDP2P, or 3,4-methylenedioxyphenyl-2-propanone.) There are a lot of oxidization reactions available, but in this case we of course want something that will produce the Markovnikov product, with addition occurring at the more substituted end of the alkene. 2-Chlorophenyl cyclopentyl ketoneAn initial oxidation to an alcohol followed by a second oxidation step to a ketone is also a possibility. Since safrole and PMK are carefully watched and regulated precursors, the current favorite precursor (typically bought from Chinese chemical manufacturers) is PMK glycidate. 2-Chlorophenyl cyclopentyl ketone


PMK glycidate can reportededly be easily broken down into PMK simply by refluxing it with hydrochloric acid. (But read on about the chemical watch lists!) 2-Chlorophenyl cyclopentyl ketone

Step 2: Reversible imine formation (occurs spontaneously when the ketone is placed in solution with methylamine freebase (not the hydrochloride salt.)

Step 3: Reduction (via hydrides, aluminum-mercury amalgams, or electrical cells) or catalytic hydrogenation permanently converts the imine to MDMA.

Since ketones and imines lack a chiral center, they (like a good Buddhist monk) do not project personal desires on the world, so the resulting product is racemic, containing a 50-50 mix of both the stronger S(+) isomer (which releases plenty of serotonin, dopamine and norepinephrine) and the weaker R(-) isomer (which is effectively just a serotonin releaser.) All MDMA sold on the streets appears to be racemic.

A product containing only one isomer would not subjectively feel the way racemic MDMA does, being either more amphetamine-like or more sedating and mellow (like MDEA, which seems to be primarily a serotonin releaser.) Safrole is found in various “essential oils”, the most famous of which is sassafras oil, which can contain as much as 90% safrole.

Since safrole (and isosafrole, MDP2P/PMK, and sassafrass oil) are “listed precursors” in the US they’re very hard to find. (Many remaining ‘sassafras oil’ products are now safrole-free in order to avoid regulation.) Even attempting to order one of these chemicals can bring law enforcement attention.

  • 2-Chlorophenyl Cyclopentyl Ketone The most famous route is probably one of Shulgin’s original synths from PIHKAL (third paragraph), starting with PMK (MDP2P) made from isosafrole. Isomerization of safrole is reportedly an easy operation, as described in the famous Strike synthesis collection. (A more compact review can be found in this old doc saved from Rhodium.),Shulgin’s ingenious use of aluminum foil and mercury as a reducing agent opened up a lot of possibilities for hobbyist-scale clandestine labs, but it comes with one ugly downside: Highly toxic mercury compounds. 2-Chlorophenyl cyclopentyl ketone

    The disposal of the leftover chemical waste from clan-labs has always been an environmental and public health problem, with irresponsible chemists dumping waste in ditches or even flushing it down the drain into sewer systems. 2-Chlorophenyl cyclopentyl ketone

    Mercury-aluminum amalgam is an interesting little reagent. Aluminum has a low electronegativity, which suggests that it would react very readily with anything mildly electron-hungry (such as the carbon atom of an imine, or the hydrogen atoms of water.) And yet, aluminum is considered corrosion-resistant under most conditions, to the point that it’s even used as shipping containers for nitric acid! That’s because, although aluminum does react readily, it tends to form aluminum oxide.

    This aluminum oxide forms a tightly interlocking crystalline layer over the remaining aluminum, sealing it off and protecting it from further


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